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On the other side of the spectrum, the only FDA-approved glutamine therapy is in sickle cell disease (SCD) patients of all ages based on a Phase III clinical trial where L-glutamine was well tolerated and reduced pain crisis [96]

Concentration of 4-6% is better for helping with acne and balancing the sebum production Helps attract water to the upper layer of the skin and can help improve skin barrier function A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation

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For a broader explanation of how this gap is evaluated across peptide categories, see Peptide Research vs Human Use and Peptide Side Effects